The spectrum of clinical syndromes termed chronic heart failure (CHF) represents the advanced, terminal stage of progression in a variety of heart conditions. The troubling upward trend in morbidity and mortality is impacting human health and life expectancy. The causes of congestive heart failure encompass a spectrum of intricate and diverse diseases, ranging from coronary heart disease and hypertension to diabetes and cardiomyopathy, and more. To comprehensively research the pathogenesis of CHF and develop novel preventive and therapeutic drugs against different disease-induced CHF, the establishment of animal models specific to various etiologies is paramount. This paper, categorized by the etiology of CHF, summarizes animal models commonly used in CHF research in the last ten years. The focus is on their application in traditional Chinese medicine (TCM) research. The aim is to provide ideas for exploring the development and treatment of CHF, ultimately promoting modernization within TCM.
This 2021 paper highlighted the 'eight trends' of the Chinese medicinal materials (CMM) industry, followed by a discussion on the problems faced by CMM production and the proposed development strategies. In particular, the following eight trends can be summarized:(1) Stable expansion was observed in the CMM sector, alongside the commencement of local Dao-di herb catalog releases by certain provinces. Doxycycline Hyclate in vitro New variety protection procedures were expedited, resulting in the cultivation of several exceptional plant varieties. With ecological cultivation theory receiving further refinement, the demonstrable impact of the cultivation technology was readily apparent. Doxycycline Hyclate in vitro Complete mechanization in some CMM systems produced exemplary model cases. Growing numbers of cultivation bases began using the traceability platform, alongside the setting up of provincial internet trading platforms. The acceleration of CMM industrial cluster construction coincided with a sharp rise in the number of provincial-level regional brands. With a surge in agricultural business entities across the nation, diverse techniques were employed to facilitate the intensified development of CMM. The promulgation of a number of local TCM laws followed the issuance of management regulations for food and medicine homology substance catalogs. For this reason, four suggestions for optimizing CMM production were proposed. Expedite the development of the national Dao-di herb catalog and certify Dao-di herb production bases. The technical research and promotion of ecological forest and grassland medicinal planting practices must be significantly strengthened, with an emphasis on ecological principles. The groundwork for disaster prevention necessitates heightened focus, while the development of cutting-edge technical measures for disaster mitigation is equally important. To improve the national regular statistical system, the planted areas of routinely employed CMMs must be included.
The microbiome's and traditional Chinese medicine (TCM)'s interconnectedness has achieved considerable recognition. Doxycycline Hyclate in vitro High-throughput sequencing and multi-omics technologies have played a crucial role in the emergence of new discoveries, results, and theories in the field of microbiomics in recent years. Building upon prior investigations, this current study introduces the concept of TCM microbiomics (TCMM), an interdisciplinary endeavor focused on elucidating the functions and applications of microbiomes within herb resources, processing, storage, and clinical outcomes, employing contemporary biological, ecological, and informatic methodologies. Microbiome structures, functions, interactions, molecular mechanisms, and applied strategies are central to this subject, specifically concerning the quality, safety, and efficacy of traditional Chinese medicine. The genesis of the TCMM concept was summarized at the outset, underscoring its profound appreciation for the complexity and completeness of the microbiome. The research content and applications of TCMM in promoting herb resource sustainability, refining herb fermentation, ensuring herb storage safety, and clarifying the scientific basis of TCM theory and clinical efficacy are reviewed in this paper. In conclusion, the microbiomics research strategies and methodologies within Traditional Chinese Medicine were comprehensively detailed, drawing upon basic, applied, and systemic research approaches. TCMM is anticipated to foster the integration of traditional Chinese medicine (TCM) with cutting-edge scientific and technological advancements, thus deepening and broadening TCM's research and advancing its modernization.
As a traditional Chinese medicine dosage form, the lozenge plays a significant role. Throughout all Chinese dynasties since the Eastern Han Dynasty, traditional Chinese medical texts have meticulously documented and continually expanded its application. The distinctiveness of its pharmaceutical methods and the encompassing range of their applications are the driving forces behind its emergence, continuation, and evolution. Until this point, lozenge has held its place within the Chinese Pharmacopoeia as a distinct dosage form. Modern Chinese medicine pharmaceutics has imbued the lozenge with new significance, prompting a journey into its origins and an exploration of its value. The origin, evolution, and distinguishing features of lozenges were reviewed, placing them in the context of similar dosage forms. A comparative analysis was performed between modern and traditional lozenge formulations, with particular attention to the potential of this dosage form within the growing landscape of modern Chinese medicine preparations. The objective of this study was to contribute to the expansion of lozenge applications in modern medicine.
Human wisdom is exemplified in Traditional Chinese Medicine (TCM)'s extensive history and abundant experience in external therapy. Early humans discovered that fumigating, coating, and adhering tree branches and herb stems could alleviate scabies and remove parasites from the workforce, a crucial development that signaled the emergence of external therapy. Pathogens typically enter the human body through external surfaces, thus rendering external therapies a viable option for disease remediation. Surgery in Traditional Chinese Medicine (TCM) frequently incorporates external therapies as a significant characteristic. Through the application of external therapies to acupoints, Traditional Chinese Medicine aims to balance the zang-fu organs by regulating energy flow via meridians and collaterals, thereby fostering harmony between yin and yang. The therapy, a product of early societies, navigated the Spring and Autumn and Warring States eras, witnessing notable improvements during the Song and Ming dynasties, and achieving full maturity during the Qing dynasty. Historical experts' sustained efforts have resulted in a thoroughly developed theoretical understanding. Studies in modern medicine reveal that Chinese medicinal products can bypass the liver's first-pass effect, reduce gastrointestinal irritation, and improve how well the body absorbs them. Utilizing the meridian and collateral theory within Chinese medicine, stimulation and regulation of acupoints amplify the efficacy of Traditional Chinese Medicine and the cooperative action of the two. In this manner, it regulates the circulation of qi and blood, and balances yin and yang, which explains its broad application in treating diseases. This literature review synthesized the effects of external application to acupoints on skin immunity, neuro-inflammatory regulation, human circulatory network correlations, and dosage form innovations. This study is anticipated to create a framework for further research, leveraging the principles detailed here.
In response to the cyclical variations in the environment, organisms develop an internal regulatory mechanism, circadian rhythm, that controls pathological events, disease progression, and the body's reaction to treatment in mammals. Ischemic stroke's susceptibility, injury, recovery, and reaction to treatment are substantially influenced by this. Research indicates circadian rhythms exert control over not only essential physiological processes in ischemic strokes, including blood pressure and coagulation-fibrinolysis, but also the immuno-inflammatory response initiated by glial cells and peripheral immune cells after ischemic injury, and the regulation of the neurovascular unit (NVU). Linking molecular, cellular, and physiological circadian pathways in biology to clinical consequences of ischemic stroke is the aim of this article. It will demonstrate the impact of circadian rhythms on ischemic stroke's progression, neurovascular unit activity, and associated immuno-inflammatory processes. We evaluate the role of traditional Chinese medicine in synchronizing circadian rhythms, compiling current research on TCM's interventions. A crucial resource is provided for continued study in TCM and its molecular underpinnings of circadian rhythms.
Actively dividing transit amplifying cells (TACs) reside within hair follicles (HFs), making them acutely vulnerable to radiotherapy (RT). Clinically, radiotherapy-induced alopecia (RIA) unfortunately lacks sufficient treatment options.
The effect of local prostaglandin E2 (PGE2) treatment on RIA prevention, and the mechanisms involved, were the focus of this current study.
In a living mouse model, we evaluated the impact of radiation on the development of high-frequency cells, contrasting the results with and without prior local treatment with PGE2. A study of PGE2's impact on the cell cycle was conducted using cultured HF cells, which were obtained from mice expressing a fluorescent ubiquitination-based cell cycle indicator. Moreover, we compared the safeguarding properties of PGE2 and a cyclin-dependent kinases 4/6 (CDK4/6) inhibitor to RIA's effects.
By promoting self-repair within the heart's high-frequency system, the local cutaneous PGE2 injection curtailed RIA.